Long-term production of ergot peptides by immobilized Claviceps purpurea in semicontinuous and continuous culture

Article Abstract:

Continuous and semicontinuous cultures of Claviceps purpurea 1029/N5 were achieved by immobilization on calcium alginate beads. Mycelial immobilization resulted in prolongation of growth and production of ergotamine. Optimal ergotamine production occured by increasing calcium chloride concentration, which prolonged the productive phase. In addition, restricting the phosphate supply inhibited the production of outgrowing hyphae.

Microbial biotechnology

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Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis

Article Abstract:

The Claviceps fusiforms ergot alkaloids synthesis (EAS) is analyzed in order to examine the evolutionary basis for chemotypic differences between the Claviceps species. The studies have shown that the Claviceps fusiformis EAS cluster has evolved from a more complete cluster by loss of some lps gene and by rearrangements and mutations inactivating lpsB and cloA.

Science & research, Genetic aspects, Genetic research, Claviceps

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Chemoraces and habitat specialization of Claviceps purpurea populations

Article Abstract:

Researchers identified three groups of Claviceps purpurea that occupied different habitats. One was found in fields and open meadows, one in shady or wet habitats, and one in salt marshes. Techniques included randomly amplified polymorphic DNA, EcoRI restriction site polymorphisms in 5.8S ribosomal DNA, alkaloids, and conidial morphology.

Morphology (Biology), Ergot

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