Looping versus linking: toward a model for long-distance gene activation

Article Abstract:

The article examines locus control regions (LCRs) associated with the b-globin locus in mammals, and an open chromatin domain and direct gene activation as the high level of expression driven by the LCR. The linking model of gene activation and DNA looping are discussed.

Research, DNA, Chromatin, Molecular biology, Heredity

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Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior

Article Abstract:

The authors have investigated Hox proteins. The ability of this proteins to recognize their target sites and compete for DNA sites of anterior Hox proteins has been studied via the use of the posterior prevalence model, and the authors discuss the details.

Peptides, DNA-ligand interactions, DNA binding, Structure, Genes

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Synapse disassembly

Article Abstract:

The authors review publications on synapse disassembly. The topics include the analysis of phenomenology and mechanisms of this disassembly.

Physiological aspects, Cells (Biology), Cells, Ligands (Biochemistry)

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