Loss of function of def selectively up-regulates delta113p53 expression to arrest expansion growth of digestive organs in zebrafish

Article Abstract:

Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. A study was conducted to find out if or how the p53 pathway functions during organogenesis and it was evidenced that the zebrafish DEF (digestive-organ expansion factor) gene encodes a novel pan-endoderm-specific factor and while induction of expression of p53 or its isoforms is crucial to suppress abnormal cell growth.

United States, Cell cycle, Zebra fish, Zebra fishes

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

Article Abstract:

Mdm2-dependent NEDD8 modification of p53 inhibits its transcriptional activity, which is demonstrated using a cell line (TS-41) with a temperature-sensitive mutation in the NEDD8 conjugation pathway and a p53 mutant that cannot be NEDDylated (3NKR). The role of Mdm2 as an E3 ligase provides evidence that Mdm2 is a common component of ubiquitin and NEDD8 conjugation pathway.

Gene mutations, Gene mutation, Cell lines, Genetic research, Ubiquitin

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p53 isoforms can regulate p53 transcriptional activity

Article Abstract:

The p53 gene, like p73 and p63 genes, contains an internal promoter and can transcribe six different mRNAs in normal human tissue, which can encode at least six p53 protein isoforms. The differential expression of the p53 isoforms in human tumors might explain the difficulties in linking p53 status to the biological properties and drug sensitivity of human cancer.

Cancer, Oncogenes

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