Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes

Article Abstract:

The incorporation of labeled amino acids into polypeptides during sperm capacitation, which was completely inhibited by mitochondrial translation inhibitors but not by the cytoplasmic translation inhibitors, is demonstrated. The ability of spermatozoa to synthesize proteins, including nuclear-encoded proteins by 55S ribosomal machinery is critical for the final maturation step leading to successful fertilization.

Genetic aspects, Mitochondrial DNA, Spermatozoa, Sperm, Fertilization (Biology)

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

Article Abstract:

Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC) and that Notch3 is required for arterial specification of vSMC but not of endothelial cells. The data from observation on Notch3 mice reveal Notch3 to be first cell-autonomous regulator of arterial differentiation and maturation of vSMC.

Mice as laboratory animals, House mouse, Vascular smooth muscle

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Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells

Article Abstract:

Studies show that Beta/Beta mice lived longer and had higher energy expenditure than their control littermates due to elevated White Adipose Tissue (WAT) energy oxidation. The WAT of Beta/Beta mice were enriched with metabolically active, thermogenic mitochondria known for energy dissipation.

Mitochondria, Adipose tissues, Adipose tissue

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