Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNFalpha and notch

Article Abstract:

Metalloprotease-disintegrins are a group of glycoproteins that are membrane anchored and comprised of various distinct protein modules such as pro- and metalloprotease domain, EGF repeat, cysteine-rich region and disintegrin domain. Previous genetic studies on Drosophila reveal that the glycoprotein Kuzbanian influence neural cell fate promotion and inhibition at various neurogenesis stages. They also indicate that metalloprotease-disintegrins affect the cleaving of proinflammatory membrane-anchored cytokine tumor necrosis alpha.

Glycoproteins, Cell adhesion, Metalloenzymes

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

Article Abstract:

A polypeptide ligand for osteoprotegerin, a member of the tumor necrosis factor family of cytokines found in transmembrane and soluble forms, was characterized. The ligand binds to the surface of osteoclast progenitors in bone marrow treated with CSF-1. Recombinant soluble osteoprotegerin ligand strongly induces bone resorption in vivo and, along with osteoprotegerin, acts as positive and negative regulators of osteoclast development.

Physiological aspects, Bone marrow, Ligands (Biochemistry), Ligand binding (Biochemistry), Cytokines

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