Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications

Article Abstract:

An in vitro acetylation reaction was performed on chromatin isolated form PRMT1-depleted cells to determine whether the effect on acetylation was directly related to the loss of histone H4 Arg3. The result shows that H4 Arg 3 methylation by PRMT1 appears to be essential in vitro for the establishment or maintenance of a wide range of active chromatin modifications.

Arginine, Methylation, Chemical properties

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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Article Abstract:

GLP and G9a-related methyltransferases are the mammalian histone H3 Lys 9 (H3-K9) methyltransferase that targets euchromatic regions and is essential for murine embryogenesis. The findings carried out on the GLP and G9a shows that both exert H3-K9 methyltransferase function in vivo, by the formation of higher-order heteromeric complexes.

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Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors

Article Abstract:

The established regulation of knirps by Drosophila Tailless (Tll) nuclear receptor is used as a model to show that repression of knirps by Tll involves Atrophin, which is related to vertebrate Atrophin-1 and Atrophin-2. Atrophin interacts with Tll physically and genetically and both proteins localize to the same kirps promoter region.

Physiological aspects, Nucleoproteins, Drosophila

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