Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus

Article Abstract:

The place cells of transgenic mice exhibiting mutated Ca2+/calmodulin-dependent protein kinase II (CaMKII) with normal high frequency long-term potentiation (LTP). The transgenic hippocampal CA1 pyramidal cells are composed of 31% place cells compared to the wild-type hippocampus which is composed of 58% place cells. The CA1 pyramidal cells of the CaMKII-Asp286 transgenic mice also exhibited weaker positional firing patterns indicating the presence of less compact place fields compared to wild type CA1 positional firing.

Physiological aspects, Genetically modified mice, Neural transmission, Synaptic transmission, Hippocampus (Brain)

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Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: A function for local protein synthesis in memory storage

Article Abstract:

Synaptic plasticity enables neurons to control the strength of their synaptic connections, and contributes to many physiological and pathological processes in the brain. Aplysia sensory-motor neuron cultures were examined to determine whether individual neurons show synapse specificity. Presynaptic sensory neuron axons deprived of their cell bodies were found to be capable of protein synthesis.

Observations, Proteins, Protein synthesis, Aplysia

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