The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar purkinje cells

Article Abstract:

Research demonstrates that HCN1 channel is essential both for learning and memory of motor behaviors of relatively rapid, repeated, and coordinated movements and in integration of inputs by cerebellar Purkinje cells. Data show that HCN1 stabilizes Purkinje cell generated input-outut properties thus facilitating plasticity in the cerebellar cortex, which modulate the repetitive motor activity.

Physiological aspects, Learning, Motor ability, Motor skills, Neurobiology, Memory, Neuroplasticity

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

Article Abstract:

The abolition of the lethality and neurodegeneration caused by deletion of CSPalpha, by transgenic expression of alpha-synuclein, is reported. Observations reveal a powerful in vivo activity of alpha-synuclein in protecting nerve terminals against injury and suggestions that it operates in conjunction with CSPalpha and SNARE proteins on the presynaptic membrane interface are put forth.

Prevention, Nervous system, Gene expression, Neurodegenerative diseases

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