Model systems in stem cell biology

Article Abstract:

Answers to the queries of the nature of stem cells, their common characteristics, their non-negligible difference and their possible developmental species specificity are necessary for inferring anything about human stem cell biology. The creation of novel model systems in stem cell biology, human-to-animal embryonic chimeras, is discussed.

Biological assay, Bioassay, Chimeras (Organisms)

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Controlling the stem cell niche: Right time, right place, right strength

Article Abstract:

The importance of beta-catenin for the maintenance of the stem cell pool in the tissue is discussed. Different responses can be induced by a gradient in Wnt/beta-catenin activity levels within distinct cell populations reflected by activation of distinct transcriptional profiles.

Germany, Physiological aspects, Mammals, Homeostasis

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