Molecular analysis and developmental expression of the focal adhesion kinase pp125(super FAK) in Xenopus laevis

Article Abstract:

Research results suggest that focal adhesion kinase (FAK) plays a role in a number of signaling events involving integrin and the extracellular matrix during morphogenesis. The cDNA cloning and sequencing analysis of the Xenopus laevis homolog of pp125(super FAK) showed more than 90% identity in Xenopus FAK with its homologs in birds and mammals. Xenopus FAK expression occurs from fertilization on. The FAK expressions correlate with developmentally regulated events like gastrulation and the formation of somites. Phosphotyrosyl-FAK is first found during gastulation, indicating the developmental regulation of phosphorylation of FAK on tyrosine.

Analysis, Cloning, Morphogenesis, Xenopus, Cell adhesion

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Unmasking mRNA in clam oocytes: role of phosphorylation of a 3' UTR masking element-binding protein at fertilization

Article Abstract:

A study was conducted to investigate the activation of dormant maternal mRNAs during meiosis or at fertilization in the clam, Spisula solidissima, using UV-crosslinking and gel retardation assays. The results showed that the interaction between clam oocyte proteins and the masking elements of ribonucleotide reductase and cyclin A mRNAs influences translational unmasking of mRNA in clam oocytes. Phosphorylation of a 3' untranslated region was identified to be the key step in the regulation of translational unmasking.

Genetic regulation, Fertilization (Biology), Clams

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Expression of activin mRNA during early development in Xenopus laevis

Article Abstract:

Researchers analyzed the localization of the mRNAs encoding the activin betaA and betaB subunits in Xenopus embryos to identify the source of activin protein for initial mesoderm induction, and to discover whether activins could further influence embryonic development for the induction. Activin betaA and betaB mRNAs were discovered in the follicle cells around oocytes but not in oocytes themselves or fertilized eggs.

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