Molecular genetic analysis of the mld (super r) mouse: a spontaneous revertant at the mld locus containing a recombinant myelin basic protein gene

Article Abstract:

A new mouse mutation which arose from a colony of mld revertant mice was discovered and the reversion was found to be allelic to mld. The revertant mouse was distinct for the absence of hypomyelination. Genetic and molecular studies showed that the mld (super r) mutation was caused by recombination of the 5' end of the rearranged myelin basic protein (MBP) gene with the 3'end of the downstream MBP gene. The MBP gene expression in revertant mice was similar to wild-type gene on the basis of developmental regulation, level of expression and post-transcriptional processing of MBP gene products.

Genetic aspects, Myelin proteins, Chromosome abnormalities, Molecular genetics

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Genetic instability within monotonous runs of CpG sequences in Escherichia coli

Article Abstract:

Introducing an ApT or a GpT dinucleotide in a repetitive (GpC)(sub n) sequence in Escherichia coli reduces the rate of deletions, but a purine-pyrimidine dinucleotide increases the rate of deletion. Deletions constitute deviations from the normal DNA sequences where mutations could exist. The purine-pyrimidine sequence indicates that the (GpC)(sub n) runs are responsible for Z-DNA structure while ApT substitution indicates that (GpC)(sub n) allows formation of DNA structures participating in frameshift mutagenesis.

Usage, Observations, Escherichia coli, Nucleotide sequence, Base sequence

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Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine

Article Abstract:

The phenotype of a new insertional mutation, TgN(Imusd)370Rpw, that causes a kink at the end of the tail in transgenic mice, has been identified and characterized. Molecular characterization of the insertion site indicates that the transgene integration has occurred without any substantial alterations in the structure of the host sequence. Using probes that flank the insertion site, the mutation to chromosome 5 near the semidominant mutation, thick tail, has been mapped.

Analysis, Phenotype, Phenotypes

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