Monte Carlo pedigree disequilibrium test for markers on the X chromosome

Article Abstract:

A disequilibrium test applicable to pedigrees and X-chromosomal markers is proposed and is extended to accommodate missing genotypes through a Monte Carlo (MC) estimation procedure. It is observed that the MC version of the X-chromosomal pedigree disequilibrium test is a valid test for association under linkage with the assumption that the pedigrees and their associated affection patterns are drawn randomly from a population of pedigrees with at least one affected offspring.

Science & research, X chromosome, Pedigree analysis

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Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility

Article Abstract:

Optimal marker characteristics and feasibility in genome screens using linkage disequilibrium (LD) tests are discussed with crucial information for designing effective screening studies for markers that show LD with a disease locus, comparing diallelic markers to multiallelic markers. Findings indicate use of multiallelic markers is the better choice in almost all cases.

Economic aspects, Genomes, Mendel's law, Mendel's laws, Familial diseases, Genetic research, Linkage (Genetics)

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Disequilibrium likelihoods for fine-scale mapping of a rare allele

Article Abstract:

A likelihood-based method of fine-scale mapping of a rare monophyletic disease is presented and applied, as an example, to the Werner syndrome in the Japanese. The method depends on a coalescent model of the ancestry of a sample of disease alleles and involves only disequilibrium mapping for a rare allele that is monophyletic in origin.

Japan, Models, Statistics, Genetic recombination, Allelomorphism, Alleles

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