Mouse models of human single gene disorders I: non-transgenic mice

Article Abstract:

The large numbers of progeny and existence of inbred strains makes the mouse a good genetic model for studying single gene disorders in man. Comparison of phenotypic similarities in man and mice led to the dicovery of genetic disorders such as Chediak-Higashi and Waardenburg syndromes. Genetic mapping of mutated mice may predict the equivalent mutations in man. When the genes involved in human disease and the mouse mutant are homologous and mutated, the mouse is deemed a definite genetic model. This can be used in studying the mechanisms of human disease and in testing their possible treatments.

Models, Usage, Evaluation, Biological models, Genetic disorders, Genetically modified mice

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Interviews on genomics

Article Abstract:

Genetic scientists James D. Watson and Russell Doolittle firmly believe that despite trepidations from various sectors the Human Genome Project and other efforts toward human genome mapping will have vast benefits to medical practice and other biological sciences. More notably, genomics has contributed to understanding specific disease genes such as breast cancer and Alzheimer's disease. Moreover, inroads to genomics and biotechnology will change the way people see themselves in relation to the rest of the living world.

Social aspects, Interview, Scientists, Human Genome Project, Watson, James D., Doolittle, Russell

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Early mouse embryo development: could epigenetics influence cell fate determination?

Article Abstract:

Epigenetic influence on the early mouse embryo development was studied. Torres-Padilla et al. have recently shown that epigenetic information, histone arginine methylation mediated by CARM1 could contribute to cell fate decisions in the mouse 4-cell-stage embryo.

Analysis, Physiological aspects, Embryo, Epigenetic inheritance

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