A model for antagonistic pleiotropic gene action for mortality and advanced age

Article Abstract:

A model has been developed for antagonistic pleiotropic gene action for old age and mortality. Association or linkage studies relating to control and long-lived populations give information on genes that influence length of life. The relationship between allele-specific differences in survival and the genetic structure of aging cohorts is not well understood. A heterogeneous cohort with several genotypes with differences in age-specific mortality has been modeled. The model makes it possible to derive a fundamental property underlying abrupt age-related changes in the composition of a cohort.

France, Health aspects, Aging, Usage, Mathematical models, Biological models, Longevity, Geriatric pathology

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Linkage analysis of X-linked cone-rod dystrophy: localization to Xp11.4 and definition of a locus distinct from RP2 and RP3

Article Abstract:

A linkage analysis of X-linked cone-rod dystrophy (COD1) has narrowed the locus to a limited section of Xp11.4, distal to DXS993 and proximal to DXS556, a length of about 1.0 Mb. The locus is well enough defined for positional cloning. The results also show that the COD1 gene cannot be an allelic variant of RP3, a gene for retinitis pigmentosa.

Retinal degeneration

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