Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein

Article Abstract:

A novel beta-catenin-interacting protein, ICAT, has been identified. It has been found to inhibit interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated transactivation. ICAT inhibits Xenopus axis formation in that it interferes with Wnt signaling. It appears likely that ICAT negatively regulates Wnt signaling by inhibition of the interaction of beta-catenin with TCF. It is also integral in development and cell proliferation.

Genetic aspects, Proteins, Developmental biology, Embryology, Experimental, Embryological research, Xenopus, Heredity

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

Article Abstract:

Multiple Ras-dependent phosphorylation pathways have been found to regulate Myc protein stability. Two N-terminal phosphorylation sites in Myc , Thr 58 and Ser 62 were investigated. A synergistic role for multiple Ras-mediated phosphorylation pathways in the control of Myc protein accumulation during the first stage of cell proliferation has been defined.

United States, Cells (Biology), Growth, Cells, Phosphorylation, Ras genes

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Regulation of CDK4 activity by a novel CDK4-binding protein, p34(super.SEI-1)

Article Abstract:

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(super.SEI-1), is discussed. The p16(super.INK4a) tumor suppressor works against cyclin-dependent kinases, CDK6 and CDK4. The novel gene SEI-1, the product of which seems to work against the function of p16(super.INK4a), has been isolated.

United Kingdom, Statistical Data Included, Carrier proteins, Transport proteins, Cell cycle, Protein kinases, Mammals, Tumor suppressor genes

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