Generation of superhelical torsion by ATP-dependent chromatin remodeling activities

Article Abstract:

Research shows that ATP-dependent chromatin remodeling generates negative superhelical torsion in DNA and chromatin during gene regulation. Data indicate that all Snf2p-related ATPase motors possess this activity as exemplified by the yeast SWI/SNF complex, Xenopus Mi-2 complex, recombinant ISWI and BRG1.

Scotland, Torsion, Adenosine triphosphate, ATP

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Regulation of CSF1 promoter by the SWI/SNF-like BAF complex

Article Abstract:

Research has been conducted on the mammalian BAF complex which regulates gene expression via modifying chromatin structure. The genes activated and the genes repressed by the BAF complex in SW-13 cells have been identified and the model in which the BAF complex promotes Z-DNA formation stabilizing the chromatin structure at the human colony-stimulating factor 1 has been created and described.

Statistical Data Included, Cells (Biology), Cells

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Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation

Article Abstract:

The authors review the publications on histone lysine methylation. The topics of interest include the role of this methylation in chromatin structure organization and gene expression regulation.

Histones, RNA polymerases, Phosphorylation, Methylation, Structure

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