Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

Article Abstract:

Research concerning the chronic faults that emerge in hematopoiesis for mice, homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6, focussed on testing whether the faults at the me locus could be due to mutations inside the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. The similar map positions of the Hcph and me loci and the believable function of hematopoietic cell phosphatase (HCP) as a decisive signaling molecule in hematopoietic cell control and development prompted this focus. The me and mev mutations were inside the Hcph gene.

Analysis, Observations, Mice, Mice (Rodents), Hematopoiesis

---

Smads: transcriptional activators of TGF-beta responses

Article Abstract:

The transforming growth factor-beta superfamily of polypeptides have intracellular signaling mediators called Smads. These membrane proteins exhibit two large conservative domains, the MH1 or N domain and the MH2 or C domain, divided by a conserved linker segment. Smads function as type I receptor-activated signaling effectors regulating transcription of discriminate genes in reaction to ligand. The mechanism involved in the transcriptional stimulation of Smads is denoted by the combined requirements for interactions with other transcription factors.

Research, Membrane proteins, Genetic transcription, Transcription (Genetics), Transforming growth factors

---

STATs: signal transducers and activators of transcription

Article Abstract:

Signal transducers and activators of transcription (STATs) are DNA-binding proteins that were first identified in mammalian genes. Genetic mapping studies suggest that the structure of STATs are related to their function in the cell. STATs possess a conserved region that has a potential for phosphotyrosine-binding. They also contain a highly divergent carboxy-terminal domain that influences transcriptional activation. They may also form heterodimeric complexes to bind cytokines.

DNA binding proteins, Cell transformation

Similar abstracts:

• Abstracts: Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. part 2 A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size
• Abstracts: Transmission distortion at a minisatellite locus in the harlequin beetle riding pseudoscorpion. The Development of a High-Density Canine Microarray
• Abstracts: Sudden substrate dilution induces a higher rate of citric acid production by Aspergillus niger. Purification and characterization of a dimethoate-degrading enzyme of Aspergillus niger ZHY256, isolated from sewage
• Abstracts: Physical map of the chromosome of the phytopathogenic bacterium Pseudomonas syringae pv. phaseolicola. Pili of Pseudomonas syringae pathovar syringae enhance initiation of bacterial epiphytic colonization of bean
• Abstracts: Production of a non-toxic site-directed mutant of Clostridium perfringens e-toxin which induces protective immunity in mice

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.