Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase

Article Abstract:

The anthranilate phosphoribosyltransferase encoded by the trpD gene of Corynebacterium glutamicum ATCC 21850 makes C. glutamicum AS019 resistant to 5-methyltryptophan. The ATCC 21850 trpD differs from the AS019 trpD gene by two amino acids at the protein level. The ATCC 21850 anthranilate phosphoribosyltransferase is more resistant to feedback inhibition by either tryptophan or 5-methyltryptophan than its wild type. This insensitivity to tryptophan increases tryptophan biosynthesis.

Physiological aspects, Genetic aspects, Bacteria, Microbial enzymes, Tryptophan metabolism

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Reduction of selenite and detoxification of elemental selenium by the phototrophic bacterium Phodospirillum rubrum

Article Abstract:

Research conducted on the ability of Rhodospirillum rubrum to reduce selenite and to detoxificate elemental selenium is presented. Results include a demonstration of the detoxification process.

Switzerland, Toxins, Selenium, Selenium (Chemical element), Molecular microbiology, Selenite

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