Engineering increased stability in the antimicrobial peptide pediocin PA-1

Article Abstract:

Replacing the methionine-31 residue in the antimicrobial peptide pediocin PA-1 with Ala, Ile, or Leu keeps the peptide from losing activity at low temperatures without adversely affecting its antimicrobial activity. Pediocin PA-1 is used as a food preservative but it is inactivated at low temperatures.

Anti-infective agents, Bacterial toxins

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Structure-function analysis of immunity proteins of pediocin-like bacteriocins: c-terminal parts of immunity proteins are involved in specific recognition of cognate bacteriocins

Article Abstract:

The immunity proteins of pediocon-like bacteriocins show a high degree of specificity with respect to the pediocin-like bacteriocin they recognize and confer immunity to. A study was conducted to identify regions of the immunity proteins that are involved in the specific recognition.

Science & research, Microbiology, Proteins, Bacteriocins

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New biologically active hybrid bacteriocins constructed by combining regions from various pediocin-like bacteriocins: the C-terminal region is important for determining specificity

Article Abstract:

Peptide synthesis leads to development of four new biologically active hybrid bacteriocins from different pediocin-like bacteriocins, and the C-terminal region is important for determining cell specificity. The response of the different bacterial strains to a hybrid bacteriocin is the same as the C-terminal derived bacteriocin, whereas it is different from the response of the N-terminal derived bacteriocin. The presence of contaminating proteases contributes to the instability of natural bacteriocins as compared to synthetic bacteriocins.

Analysis, Influence, Cells (Biology), Proteases, Lactobacillus, Peptides, Cells, Peptide synthesis

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