Notch signaling in hematopoiesis and lymphopoiesis: Lessons from Drosophila

Article Abstract:

The role of Notch signaling in the hematopoietic system is reviewed with particular emphasis on lymphocyte development and the similarities in Notch function of Drosophila and mammalian differentiation processes are discussed. The study indicates that Notch signaling controls multiple cell fate decisions in mammals as well as invertebrates like Drosophila, and differentiation process during fetal hematopoiesis and adult lymphocyte development but more research has to be conducted to find new strategies for fighting cancer.

Drosophila, Hematopoiesis

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Meetings: Animal models of T-cell-mediated skin diseases

Article Abstract:

Pharmaceutical companies are spending increasing amounts of money on drug research, which focuses on Animal models of T-cell mediated skin diseases. The recent advances in animal research that are important for anti inflammatory drug discovery are discussed.

United States, Analysis, Skin diseases, Pharmaceutical research

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Calcineurin/NFAT signaling in the [beta]-cell: from diabetes to new therapeutics

Article Abstract:

The study presents the new advancements in the technique of calcineurin and its substrate the Nuclear Factor of Activated T-cells (NFAT) signaling in [beta]-cells. New therapeutic approaches for the treatment of diabetes are also discussed.

Physiological aspects, Diabetes, Diabetes mellitus, Pancreatic beta cells, Calcineurin

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