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The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure

Article Abstract:

The Drosophila tyrosine kinase called SH2 domain ankyrin repeat kinase (Shark) is necessary for embryonic dorsal closure. Flies with a Shark tyrosine kinase gene mutation, shark (super.1) show a DC-defective phenotype. Dpp is not expressed in shark(super.1) mutant leading edge (LE) cells. Shark regulates the NJNK signaling pathway to Dpp expression in LE cells/

Author: Fernandez, Rafael, Takahashi, Fumitaka, Liu, Zhao, Steward, Ruth, Stein, David, Stanley, E. Richard
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
Epithelial cells, Protein tyrosine kinase, Protein-tyrosine kinase

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Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

Article Abstract:

Import to the nucleus of the Rel protein, Dorsal, is regulated in Drosophila by phosphorylation. The formation of a wild-type Dorsal nuclear gradient requires the phosphorylation of both Cactus, an I-kappa-B protein, and Dorsal. The strong conservation of the serines would seem to indicate that phosphorylation of other Rel proteins is necessary for the nuclear targeting to be accurate. An in-depth study of the functional importance of Dorsal phosphorylation has been carried out, and it was found that Dorsal is phosphorylated by the ventral signal while associated with Cactus.

Author: Steward, Ruth, Drier, Eric A., Huang, Leslie H.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
Proteins, Phosphorylation, Cell receptors, Cell nuclei, Cell nucleus

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Recruitment of Nanos to hunchback mRNA by Pumilio

Article Abstract:

Recruitment of Nanos to hunchback (hb) mRNA by Pumilio is discussed. Nanos and Pumilio are trans-acting factors. Protein-protein and protein-RNA interaction assays have been done in yeast in vivo and in purified components in vitro and have shown that Nanos forms a ternary complex with the RNA-binding domain of Pumilio and the Nanos response elements (NRE). Translational regulation of hb mRNA is necessary for posterior patterning of the Drosophila embryo. Pum-like proteins from other species may act by recruiting cofactors to regulate translation.

Author: Sonoda, Junichiro, Wharton, Robin P.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
Statistical Data Included, Genetic regulation, RNA splicing, Messenger RNA, Genetic translation, Translation (Genetics)

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Subjects list: Research, United States, Genetic aspects, Cellular signal transduction, Cytochemistry, Embryology, Experimental, Embryological research, Drosophila
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