Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway

Article Abstract:

Multiple repression domains (RDs) seen in certain corepressors that mediate transcriptional repression have been shown to be nonredundant. One RD conserved in N-coR and SMRT represses transcription by interacting directly with class II HDAC4/5. Endogenous N-CoR and SMRT associate with HDAC4 in a complex that does not have HDAC1 or mSin3A. The first instance of one corepressor using definite domains to engage multiple HDAC complexes has been seen. Alternative HDAC complexes may mediate specific repression pathways in leukemic and normal cells.

United Kingdom, Chromatin, Leukemia

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A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

Article Abstract:

A core silencing mediator for retinoid and thyroid receptors (SMRT) corepressor complex with TBL1, a WD40-repeat protein linked to deafness, is discussed. The corepressor also contains HDAC3 and the complex comprises transducin beta-like protein 1 (TBL1). The TBL1 gene is mutated in human sensorineural deafness. Isolation of a SMRT-containing complex from HeLa cells has been achieved. SMRT mediates repression by thyroid hormone receptor (TR). It also mediates repression by other nuclear hormone receptors and transcription factors. Loss-of-function TR(beta) mutations bring on deafness in humans and mice. HDAC3 is a histone deacetylase that not been thought to interact with SMRT. TBL1 is bridged to HDAC3 through SMRT. It can potentiate repression by TR.

Gene expression, Thyroid hormones, Deafness, Hormone research, HeLa cells, Sensory discrimination

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Proteasomal regulation of nuclear receptor corepressor-mediated repression

Article Abstract:

Gene transcription repression is basic to nuclear hormone receptors. Cell-specific repression by nuclear receptors relates to levels of nuclear receptor corepressor (N-CoR) protein, based on recent experimentation. Aimed proteolysis of transcriptional coregulators has been found to be a path for cell-specific regulation of gene transcription.

Proteolysis

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