Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

Article Abstract:

Nucleolin and YB-1 are necessary for JNK-mediated interleukin-2 (IL-2) mRNA stabilization during T-cell activation. The mechanism for MRNA turnover has been studied using IL-2 mRNA as a model. The two major RNA proteins identified act through an NJK response element (JRE) in the 5' untranslated region (UTR). They specifically bind to the JRE and have a role for the JNK-signaling pathway.

Usage, Cellular signal transduction, Biological models

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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

Article Abstract:

Research has been conducted on the inheritably unstable mammalian mRNA containing AU-rich elements. The mechanism of the rapid mRNA degradation dictated by the AU-rich elements has been investigated via the purification and characterization of the human exosome by mass spectrometry and the results are reported.

Italy, Netherlands, Switzerland, Statistical Data Included, Analysis, Carrier proteins, Transport proteins, Cell research, Cytological research

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Nucleoin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

Article Abstract:

YB-1 and nucleolin are necessary for JNK-mediated interleukin-2 (IL-2) mRNA stabilization in T-cell activation. IL-2 mRNA was used as a model for describing the role for the NMK-signaling pathway in stabilizing IL2 mRNA in T-cell activation. Two major RNA-binding proteins were identified. They bind specifically to the JNK response element (JRE).

Genetic aspects

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