OPA1 controls apoptosis cristae remodeling independently from mitochondrial fusion

Article Abstract:

Study is presented to show that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, is found to protect from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. The results have shown that OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis.

---

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

Article Abstract:

A genetic approach is used to investigate the function of presenilin-associated rhomboid-like (PARL) and its potential role in optic atrophia 1(OPA1) processing. The results have shown that [Parl.sup.-1-] mitochondria undergo faster apoptotic cristae remodeling and cytochrome c release, implicating regulated intramembrane proteolysis in controlling apoptosis.

Causes of, Risk factors

---

OPA1 and PARL keep a lid on apoptosis

Article Abstract:

Study is presented to show that cristae remodeling during apoptosis, which leads to the release of cytochrome c, is regulated by a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1. The results have suggested that the PARL-OPA1 duo is required for maintaining the tightly folded structure of the mitochodrial inner membrane.

Similar abstracts:

• Abstracts: A reanalysis of the indirect evidence for recombination in human mitochondrial DNA. Direct evidence of recombination in human mitochondrial DNA
• Abstracts: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense
• Abstracts: Structural basis for the autoinhibition of calcium/calmodium-dependent protein kinase I. Structural analysis of autoinhibition in the Ras activator Son of sevenless
• Abstracts: Tellurite resistance and reduction by obligately aerobic photosynthetic bacteria. Anaerobic respiration on tellurate and other metalloids in bacteria from hydrothermal vent fields in the eastern Pacific Ocean
• Abstracts: Occurrence of a sequence in marine cyanophages similar to that of T4 g20 and its application to PCR-based detection and quantification techniques

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.