PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

Article Abstract:

A study was conducted to characterize PACS-1 as a member of a new gene family of cytosolic connector proteins needed for the localization of membrane proteins to the trans-Golgi network. Mouse embryo cDNA library was subcloned into pVP16 while DNA sequences were amplified by the polymerase chain reaction method. Results indicated that PACS-1 binds selectively to phosphorylated furin and supports multiple sorting systems.

Genetic aspects, Membrane proteins, Rats

---

Active and inactive protein kinases: structural basis for regulation

Article Abstract:

Protein kinases and phosphatases play an important role in cellular control and regulation. Some kinases require activation by phosphorylation and others do not. The activation segment of protein kinases and the control of its conformation via phosphorylation is governed by the sequence specificity of the kinase and the sequence in the activation segment that surrounds the phosphorylated residue.

Protein kinases

---

Lingering mysteries of ubiquitin-chain assembly

Article Abstract:

The small protein ubiquitin is often linked to substrates as a polymer that vary in both linkage and length, which has important consequences for their function. In order to know the mechanisms of ubiquitin-chain assembly, deciphering them will shed light on why substrates differ in the extent and timing of polyubiquitin modification and how ancillary ubiquitination factors function.

Science & research, Polymers, Ubiquitin, Chemical properties

Similar abstracts:

• Abstracts: RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization. The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells
• Abstracts: PAR-1 for the course of Neurodegenaration. Converting a motor to an anchor
• Abstracts: GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. DkA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP
• Abstracts: Split genes uncovered through science fusion. Nonrandom dispersal and local adaptation. Closing the gap between rocks and clocks
• Abstracts: Fecal DNA Analysis for Identifying Species and Sex of Sympatric Carnivores: A Noninvasive Method for Conservation on the Tsushima Islands, Japan

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.