PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

Article Abstract:

The Drosophila PAR-1 kinase that initiates tau toxicity by triggering a temporally ordered phosphorylation process is presented. The initiator role of PAR-1 is further underscored by mutating PAR-1 phosphorylation sites that cause a much greater reduction of overall tau phosphorylation and toxicity than mutating S202.

Phosphorylation

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Dicers at RISC: the mechanism of RNAi

Article Abstract:

Experiments conducted on genetically engineered Drosophila stains to identify mutants that had a reduced or enhanced response to dsRNA are described. The results concluded that Dicer is essential for the execution phase of RNAi and in the siRNA and miRNA pathways.

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Micro RNAs in animal development

Article Abstract:

Micro RNAs (miRNAs) are ~22 nucleotide single-stranded noncoding RNA molecules that bind to target messenger RNAs (mRNAs) and silence their expression. The importance of miRNAs in animal development and their possible roles in disease and evolution is explored.

Animal genetics, Animal development

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