Parallel DNA triplexes, homologous recombination, and other homology-dependent DNA interactions

Article Abstract:

Homologous genetic recombination is the process of genetic information exchange at equivalent positions along the length of two chromosomes with substantial overall sequence identity resulting in neither the loss nor gain of a single nucleotide at the joint. Models of homologous recombination are reviewed including the copy choice model, the Meselson-Radding model and the double-strand-break repair model. Homologous recombination forming three-stranded joint molecules resulting in DNA triplexes upon deproteination is also discussed.

Models, Recombinant DNA

---

An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

Article Abstract:

Chromosomal translocations were studied by forming a fusion oncogene to mimic homologous recombination in embryonal stem cells. The fusion oncogene consisted of the human AF9 sequences which were mated into the mouse MII gene, which contains the transcription control elements similar to human leukemia. Expression of the fused genes produced tumors in chimeric mice. Prior to the development of tumors, the embryonal cell derivatives showed forms of expansion in peripheral blood.

Genetic aspects, Translocation (Genetics), Stem cells, Leukemia, Gene fusion

---

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

Article Abstract:

A model is proposed that suggests that a relationship between telomeres, DNA replication and the DNA damage machinery is required for the formation of a functional telomere. The results have shown that the telomeres are not hidden from DNA damage machinery during the cell-cycle and that detection processing of natural chromosome ends is a necessary step for chromosome end protection.

Analysis, DNA damage, Cell cycle, DNA replication

Similar abstracts:

• Abstracts: Zaprionus tuberculatus: chromosome map and gene mapping by DNA in situ hybridization. Instability of the minisatellite sequence in the first intron of the rat renin gene and localization of the gene to chromosome 13q13 between FH and PEPC loci
• Abstracts: Somatic and germinal recombination of a direct repeat in Arabidopsis. Soybean resistance genes specific for different Pseudomonas syringae avirulence genes are allelic, or closely linked, at the RPG1 locus
• Abstracts: DNA precursor asymmetries, replication fidelity, and variable genome evolution. The evolution of floral homeotic gene function
• Abstracts: PCR amplification of ribosomal DNA for species identification in the plant pathogen genus Phytophthora
• Abstracts: Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.