Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis?

Article Abstract:

Polymorphisms of the gene controlling paraoxonase have been associated with increased risk of coronary heart disease. The exact physiological role of the serum enzyme paraoxonase is not known. However, it is a component of HDL and may provide a link between HDL levels and coronary heart disease. The oxidation hypothesis suggests a role for paraoxonase in atherosclerosis.

Health aspects, Research, Oxidation, Physiological, Physiological oxidation, Genetic polymorphisms

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A Bayesian measure of the probability of false discovery in genetic epidemiology studies

Article Abstract:

The article describe on how Bayesian false-discovery probability (BFDP) can be used for design and multiple-hypothesis' testing context providing the expected numbers of false and missed discoveries.

Bayesian statistical decision theory, Bayesian analysis, Epidemiology, Genetic research

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New perspective for the elucidation of genetic disorder

Article Abstract:

The article describes the new ways derived for the elucidation of genetic disorder like coronary heart disease, stroke, dementia, psychiatric disorder, asthma, and cancer.

Stroke (Disease), Stroke, Mental illness, Mental disorders, Genetic disorders

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