PedCheck: a program for identification of genotype incompatibilities in linkage analysis

Article Abstract:

PedCheck is a new computer program which has four error-checking algorithms to assist in identification of all Mendelian inconsistencies in pedigree data. Before linkage analysis, Mendelian inconsistencies in pedigree data must be gotten rid of. It is intended to give useful and detailed diagnostic information to help resolve errors. The program will handle large data sets quickly and efficiently and accept various input formats. Error-checking algorithms are designed to match subtlety of pedigree errors.

United Kingdom, Methods, Analysis, Software, Genotype, Genotypes, Biological models, Genetics, Linkage (Genetics)

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Congenital motor nystagmus linked to Xq26-q27

Article Abstract:

Congenital motor nystagmus (CMN) has been linked to the gene Xq26-q27. In three families with CMN inherited in an X-linked, irregularly dominant pattern, linkage and candidate gene analysis has been carried out. CMN may be X-linked or autosomal dominant or autosomal recessive. CMN is characterized by bilateral ocular oscillations that start in an infant's first 6 months.

Genetic aspects, Genetic disorders, Nystagmus

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