Pheromone response in yeast

Article Abstract:

Mating pheromone causes physiological changes in haploid yeast cells. Binding of pheromone to its specific receptor on the cell membrane causes dissociation of a GTP-alpha subunit from a G protein heterotrimer. 'Schmoo' formation occurs where projections from mating yeast cells form a zygotic bridge for cell fusion. Nuclear fusion follows with G1 cell cycle arrest for effective cytoplasmic fusion. Transcriptional induction of various genes potentiates the reponse to mating pheromone. Further studies are needed to define the other genes that govern the mechanisms of the yeast pheromone response.

Physiological aspects, Genetic aspects, Yeast, Yeast (Food product), Pheromones, Sex (Biology)

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The naturally occurring furanones: Formation and function from pheromone to food

Article Abstract:

Ascorbic acid (vitamin C) is the best known and most studied of the naturally occurring furanones. Three closely linked 4-hydroxy-3(2H)-furanones have been found to be important flavour compounds in a range of highly cooked foodstuffs. It is proposed that some furanones during evolution, were utilized by the biological world as inter-organism signalling molecules inducing certain individual responses.

Research, Food, Odors, Amino acids

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Threshold dose - response model - RIP: 1911 to 2006

Article Abstract:

An essay representing the fictional obituary of scientific concept called the Threshold Dose-Response Model which has long dominated the fields of toxicology and the broader biomedical sciences is presented.

Analysis, Dose-response relationship (Biochemistry), Dose-response relationship, Toxicology

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