Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

Article Abstract:

Phosphorylated RNA polymerase II (RNAP II) stimulates pre-mRNA splicing directly by influencing very early steps in assembly of the spliceosome. The phosphorylation status of the CTD dramatically affects activity. Hypophosphorylated RNAP IIA can inhibit the splicing which hyperphosphorylated RNAP IIO strongly activates. RNAP II is responsible for transcription of mRNA precursors in eukaryotic cells. It is likely that RNAP II also has a role in subsequent RNA processing reactions by way of interactions between the carboxy-terminal domain if the RNAP II largest subunit and processing factors.

Genetic regulation, RNA splicing

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RNA polymerase II and the integration of nuclear events

Article Abstract:

RNA polymerase II and the integration of nuclear events are discussed in this review article that covers recent progress. Studies intended to find out how RNAP II acts in the RNA processing reactions that synthesize mature mRNA are the focus.

Japan, Cytogenetics

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Strange bedfellows: polyadenylation factors at the promoter

Article Abstract:

The authors review the publications on mRNAs. The topics of interest include the study of interactions linking the events occurring at the promoter in order to define transcription start site and mRNA 5' end.

Analysis, Genetic aspects, Gene expression, Genetic research

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