Smads and early developmental signaling by the TGF-beta superfamily

Article Abstract:

The transforming growth factor beta (TGF-beta) superfamily of peptide growth factors control a range of functions of the cell, among them proliferation and apoptosis. Discovery and characterization of the Smad family of gene products has been important in progress in knowing how TFG-beta superfamily signals are transduced within the cell. A molecular framework is now known.

Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Embryology, Animal embryology

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Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

Article Abstract:

The article explores molecular principles that regulate life and death balance. A potential mechanism to convert cells from life to death in death receptor-mediated apoptosis is described.

United States, Analysis, Cell death, Cells (Biology), Cells

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