Medium-chain acids affect citrinin production in the filamentous fungus Monascus ruber

Article Abstract:

The production of citrinin by the fungus Monascus ruber can be inhibited by adding medium-chain fatty acids to the culture. Citrinin is a mycotoxin that can damage the kidneys and liver. Monascus ruber produces pigments that are used as food coloring in Asia.

Fatty acids, Fatty acid synthesis

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Production and identification of N-Glucosylrubropunctamine and N-Glucosylmonascorubramine from Monascus ruber and occurence of electron donor-acceptor and complexes in these red pigments

Article Abstract:

The production and identification of N-glucosylrubropunctamine and N-glucosylmonascorubramine from Monascus ruber and the occurrence of electron donor-acceptor complexes in these red pigments were studied. The research described the extraction, purification and characterization of the structures of molecules involved in extracellular pigments. Results reveal that the use of n-butanol as an extraction solvent stabilized the pigments against the effects of daylight and that Monascus is a source of various secondary metabolites from polyketides.

Fungi, Electron donor-acceptor complexes, Glucose

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Biosynthetic pathway of citrinin in the filamentous fungus Monascus ruber as revealed by 13C nuclear magnetic resonance

Article Abstract:

Carbon-13 nuclear magnetic resonance is used in studying the biosynthetic pathway of citrinin in the filamentous fungus Monascus ruber. Citrinin is a mycotoxin with antibiotic properties against gram-positive bacteria but is not used as a therapeutic drug because of its nephrotoxic effects. Results of carbon isotope distribution of (13C)citrinin from M. ruber incubated with (13C) acetate shows that the biosynthesis of the toxin originated from a tetraketide. The tetraketide branch point may be behind the production of polyketide red pigments and citrinin.

Physiological aspects, Biosynthesis, Molds (Fungi)

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