Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

Article Abstract:

An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) is developed by expressing 17 new heterologous genes in a 6-deoxyerythronolide B (6dEB) producer strain. The megalomicin gene cluster is used as the source for the construction of two artificial operons that contained the genes encoding the deoxysugar biosynthetic and tailoring enzymes necessary to convert 6dEB to Ery C.

Erythromycin

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Recovery of Escherichia coli from soil after addition of sterile organic wastes

Article Abstract:

A hypothetical study was conducted to prove that addition of biosolid nutrients to soil would enhance recovery of Escherichia coli naturally found in soil. The experimental effect was most marked for the deeper soil layers, with increases of about 2.6 orders of magnitude in E. coli most probable number.

Microbial growth, Organic wastes

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Stress responses as a tool to detect and characterize the mode of action of antibacterial agents

Article Abstract:

Research conducted on stress and cold shock responses in Escherichia coli to detect and characterize antibacterial compounds is presented. Results include natural source antibiotics identification.

Analysis, Usage, Antibiotics, Physiological aspects, Antibacterial agents, Strains and stresses, Stresses (Materials), Biotechnology, Temperature

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