Protein F, a fibronectin-binding protein of Streptococcus pyogenes, also binds human fibrinogen: isolation of the protein and mapping of the binding region

Article Abstract:

A type-variable lipoproteinase was discovered during the screening of a gene library of Streptococcus pyogenes type M15 for fibrinogen-binding material. This component exhibits similarities with the fibronectin-binding protein F. Test results indicate the need to purify the protein to reveal its binding attributes. Moreover, the amino acid sequence variability of protein F is observed to be different compared with other M-types of S. pyogenes.

Streptococcus pyogenes, Microbial enzymes, Fibronectins, Fibrinogen

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Structural basis of pore formation by the bacterial toxin pneumolysin

Article Abstract:

The structures of membrane-surface bound (prepore) and inserted-pore oligomer forms are determined by using cryo-EM and image processing. These structures provide a direct observation of the conformational transition into the pore form of a cholesterol-dependent cytolysin.

Science & research, Bacterial toxins, Oligomers, Cell anatomy

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