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Functional discovery via a compendium of expression profiles

Article Abstract:

One assay can be used to monitor hundreds of cellular functions at the same time. A reference database, a compendium of expression profiles, corresponding to 300 different mutations and chemical treatments in S. cerevisiae has been put together. The cellular pathways affected can be found by pattern matching even when profiles are very subtle.

Author: Hughes, T.R., Marton, M.J., Jones, A.R., Roberts, C.J., Stoughton, H.A., Armour, C.D., Bennett, H.A., Coffey, E., Dai, H., He, Y.D., Kidd, M.J., King, A.M., Meyer, M.R., Slade, D., Lum, P.Y., Stepaniants, S.B., Shoemaker, D.D., Gachotte, D., Chakraburtty, K., Simon, J., Bard, M., Friend, S.H.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Drugs, Statistics, Gene expression, Genomes

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Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology

Article Abstract:

A challenge for bioinformatics and post-genome biology brought by research into protein diversity from alternative splicing is discussed in this minireview article. Splicing analysis can be seen as a fine brush on the genome. A global view of splicing regulation is needed for a picture of the total complement of proteins of an organism, and it must be combined with detailed understanding of its mechanisms if understanding of how the complement changes with development/environment is to be gained.

Author: Black, Douglas L.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Information management, Information services, Genetic engineering, Proteins, Chromosome mapping, Molecular biology, Drosophila, Molecular biologists

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The rde-1 gene, RNA interference, and transposon silencing in C. elegans

Article Abstract:

The mechanism of RNAi and the possibility that a natural function of RNAi is transposon silencing are discussed. The identification of RNA interference-deficient (rde) mutants in Caenorhabditis elegans (nematodes) is discussed. C. elegans mutants resistant to double-stranded RNA (dsRNA)-mediated interference (RNAi) were used to study the interference process.

Author: Fleenor, Jamie, Timmons, Lisa, Fire, Andrew, Grishok, Alla, Mello, Craig C., Sarkissian, Madathia, Tabara, Hiroaki, Kelly, William G.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
Statistical Data Included, Cellular signal transduction, RNA, Caenorhabditis elegans, Transposons

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Subjects list: Research, United States, Usage, Physiological aspects, Cytochemistry, Databases, Genetic aspects, Messenger RNA
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