Secondary structure of vertebrate telomerase RNA

Article Abstract:

Telomerase has 10 helical domains that are present in all organisms studied, including 18 mammals, 2 birds, 1 reptile, 7 amphibians and 4 fishes. Other regions vary considerably in both length and amino acid sequence.

Proteins, Protein structure

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Template boundary definition in mammalian telomerase

Article Abstract:

Recombinant telomerase enzyme reconstituted in vitro and in vivo is generated to determine if a region upstream of the template in mammalian telomerase RNA is important for boundary definition. The divergent structure of boundary definition suggests diverse mechanisms for template boundary definition in telomerase.

Science & research, Genetic aspects, RNA, Mammals, Genetic research

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

Article Abstract:

Telomerase activation and telomere shortening in mouse and human cells were examined to identify effects on tumor formation where culture of mouse cells show spontaneous immortalization which can best contribute to understanding tumorigenesis. The telomerase RNA component (mTR) in the mouse germline was deleted to identify telomerase activity. Results show that telomere shortening in human and mouse cells follow the same process. Lack of telomerase causes telomere shortening which does not affect tumorigenesis in mouse cells.

Cancer research, Cover Story, Telomeres, Cancer, Carcinogenesis

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