Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz

Article Abstract:

Star and Rhomboid have been found to facilitate processing and presentation of the Drosophila TGF-alpha homolog Spitz. To test certain models, an assay based on Xenopus animal caps has been developed. Spi activates DER, the epidermal growth factor receptor, in a Rhomboid and Star-dependent way in these animal caps.In one model Rhomboid and Star regulate processing of membrane-bound Spi to an active soluble form Other models would have Rhomboid and Star regulating receptor function or involved in formed a complex at the cell surface bringing recedptor and ligand together.

Proteins, Genetic regulation, Homology (Biology), Cells, Ligands (Biochemistry), Xenopus, Cell membranes, Cell permeability, Plasma membranes, Transforming growth factors, Epidermal growth factor, Epidermal growth factors

---

Receptor tyrosine kinases: specific outcomes from general signals

Article Abstract:

Receptor tyrosine kinases (RTK) and specific outcomes from general signals are discussed in this review article which deals with why one cell may become a neuron in response to RTK activation and another might become an adipocyte. Topics include models for RTK signaling specificity, the role of the DER RTK in inducing specific gene expression in the developing Drosophila eye, evidence for a difference between Sevenless and DER signaling. Individual cells often have fates established by activating transmembrane receptors of the Receptor Tyrosine Kinase family.

---

Nrarp is a novel intracellular component of the Notch signaling pathway

Article Abstract:

Nrarp, which in embryos promotes loss of the intracellular domain (ICD) has been found to be an intracellular component of the Notch signaling pathway based on work in Xenopus embryos. Nrarp (ital) is in the Delta-Notch synexpression group. It encodes a small protein with two ankyrin repeats. Nrarp may be a negative feedback regulator for Notch signaling and attenuate ICD-mediated transcription.

Germany

Similar abstracts:

• Abstracts: act up controls actin polymerization to alter cell shape and restrict hedgehog signaling in the Drosophila eye disc
• Abstracts: Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase
• Abstracts: A critical role for amino-terminal glutamine/aspargine repeats in the formation and propagation of a yeast prion
• Abstracts: The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.