Putting boundaries on silence
Article Abstract:
The eukaryotic chromosome is a combination of silenced and a tive domains with the largest blocks of silent chromatin the heterochromatic masses associated with centromeric regions and telomeres. The regions are often visibly condensed through the cell cycle and have numerous repetitive sequences. They are lacking in genes, though not devoid of them, and replicated late in the S phase. Topics discussed in this review article include boundaries to heterochromatin-like domains, barriers to spread of heterochromatin, and an insulator of enhancer function that can be in a barrier to silencing.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Biomedical discovery with DNA arrays
Article Abstract:
Biomedical discovery using DNA arrays is discussed in this review article. DNA microarray technologies make possible systematic approaches to biological discovery that are beginning to have a profound impact on medicine, biological research and pharmacology. Major conceptual and technical challenges lie in this rapidly evolving arena. Topics include transcriptional programs, gene function and drug discovery, disease diagnosis, databases with collective knowledge, prognosis and therapy, and complex biological systems.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection
Article Abstract:
Results demonstrate the transcriptional induction patterns of the Vibrio cholerae tcpA and ctxA genes during infection using a recombinase gene. Data indicate that ctxA gene induction is dependent upon tcpA expression and other virus regulators and the induction process exhibits differences during infection and growth conditions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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