QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands

Article Abstract:

A study to show that in the filamentous fungus Neurospora, the Argonaute homolog QDE-2 and its slicer function are required for the generation of single-stranded siRNA and gene silencing in vivo was conducted. Results suggest that QIP acts as an exonuclease that cleaves and removes the nicked passenger strand from siRNA duplex in a QDE-2-dependent manner and both the cleavage and removal of the passenger strand from the siRNA duplex are important steps in RNAi pathways.

Genetic aspects, Exonucleases, Neurospora

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[beta]-catenin induces immortalization of melanocytes by suppressing [p16.sup.INK4a] expression and cooperates with N-Ras in melanoma development

Article Abstract:

The stabilized [beta]-catenin has reduced the number of melanoblasts and has immortalized primary skin melanocytes by silencing the [p16.sup.Ink4a] promoter. The synergy between the Wnt and mitogen-activated protein (MAP) kinase pathways has represented an important mechanism supporting the genesis of melanoma, which is a highly aggressive and increasingly common disease.

Melanoma, Oncogenes

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Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase

Article Abstract:

The crystal structure o human SET8 bound to a histone H4 peptide bearing Lys-20 and the product cofactor S-adenosylhomocysteine is reported. SET8 is a histone H4-Lys-specific methyltransferase that is implicated in cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans.

Peptide regulatory factors, Methyltransferases

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