RNA-protein interactions in regulation of picornavirus RNA translation

Article Abstract:

An untranslated region of picornavirus directs the initiation of protein synthesis independently of the 5' end of the RNA. This region is referred to as internal ribosome entry site (IRES). The IRES directed translation is independent of its location in the mRNA, internal initiation is cap independent and does not need any viral proteins. The cardiovirus and aphthovirus IRES functions efficiently in rabbit reticulocyte lysate but enterovirus and rhinovirus IRES functions poorly. The polypyrimidine tract-binding protein, La and other proteins interact with IRES elements.

Analysis, Picornaviruses

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Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation

Article Abstract:

Mitotic clonal expansion of adipocyte differentiation is discussed with consideration of activation and centromeric localization of CCAAT/enhancer-binding proteins. These occur in the expansion. It has been shown that C/EBP-beta and C/EBP-delta, transcription factors, cannot bind to the C/EBP regulatory element in the C/EBP-alpha promoter. As the preadipocytes enter S phase and the mitotic clonal expansion begins, C/EBP-beta/delta start to acquire capacity to bind the C/EBP regulatory element and become centromere-associated.

United States, Cell cycle, Protein binding, Fat cells, Adipocytes

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Suppression of cap-dependent translation in mitosis

Article Abstract:

E-BP1, which suppresses eIF4E function, is shown to be hypophosphorylated in mitosis. Study results clarify the specific inhibition of cap-dependent translation in mitosis and how eIF4E becomes hypophosphorylated in mitosis. Inhibition of cap-dependent translation in mitosis is caused by phosphorylation modifications that lead to eIF4F complex disruption.

Canada, Physiological aspects, Cytochemistry, Ribosomes, Molecular structure

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