RNAi and double-strand RNA

Article Abstract:

Double-strand RNA (dsRNA) signals gene-specific silencing of expression in a variety of organisms. This has been demonstrated in the Caenorhabditis elegans recently. dsRNA was injected into the worm and corresponding gene products disappeared from the somatic cells and F1 progeny. The purest demonstration of mediation of gene silencing by dsRNA in plants was a study in which transgenic plants were established. They expressed either sense or antisense of a gene of the potato virus Y (PVY). Both transgenic lines of tobacco were susceptible to PVY infection, but crosses that expressed transgenes for the sense and antisense orientations became resistant to PVY. That dsRNA induces the transcriptional silencing of a specific gene, if true, would likely be important in biological phenomena of various sorts.

United States, Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Caenorhabditis elegans, Plant inspection

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Specificity of microRNA target selection in translational repression

Article Abstract:

MicroRNAs (miRNAs) are a class of noncoding RNAs found in organisms as evolutionarily distant as plants and mammals, yet most of the mRNAs, they regulate are unknown. The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA.

Evaluation, Genetic research

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A coactivator of pre-mRNA splicing

Article Abstract:

SRm160, a serine and arginine rich protein, forms a complex with SRm300 and works as a coactivator of pre-mRNA splicing. SRm160 is associated with splicing complexes and it has multiple SR repeats. However, it does not have a RNA recognition motif. It enables splicing by its interactions with other SR family proteins.

Analysis, Proteins, RNA splicing, Arginine, Serine

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