Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

Article Abstract:

The concept that an inflammatory response to commensal bacteria is avoided due to sequestration of microflora by surface epithelia is investigated and it is shown that commensal bacteria are recognized by toll-like receptors (TLRs) under normal steady-state conditions, that plays a crucial role in the maintenance of intestinal epithelial homeostatis. The findings revealed a novel function of TLRs of controlling intestinal epithelial homeostasis and protection from injury.

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Perp is a p63-regulated gene essential for epithelial integrity

Article Abstract:

Perp, a tetraspan membrane protein originally identified as an apoptosis-associated target of the p53 tumor suppressor, is the first direct target of p63 clearly involved in mediating the developmental program in vivo. The findings demonstrate that Perp is a key effector in the p63 developmental program, playing an essential role in an adhesion subprogram central to epithelial integrity and homeostasis.

Membrane proteins, Tumor suppressor genes, Tumour suppressor genes

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Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling

Article Abstract:

Studies reveal that signaling downstream from toll-Like receptors (TLRs) is initiated by the recruitment of adaptor proteins, including MyD88 and TIRAP. It is demonstrated that TIRAP and MyD88 have distinct functions and describe a mechanism of recruitment of TIRAP and MyD88 to TLR4.

Protein binding, Genetic research, Phosphoinositides, Phosphatidylinositols

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