Recruitment of p300/CBP in p53-dependent signal pathways
Article Abstract:
A study was conducted on the recruitment of p300/CBP in 53-dependent signal pathways to investigate whether p53 and p300 can be found in a specific protein complex connected to the DNA. Results reveal that p53 displays a promoter containing DNA binding sequence. On the other hand, p300 induces transcriptional processes of p53 on p53-regulated promoters. These consequently develop reponsiveness to modulators of p53 functions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Structural insights into histone demethylation by JMJD2 family members
Article Abstract:
Histone demethylases, members of an emerging transcription-factor family, remove methyl groups from the lysine residues of the histone tails and thereby regulate the transcriptional activity of target genes. Structures of the catalytic-core domain of jumonji-domain-containing histone demethylase 1 (JMJD1) with and without alpha-ketoglutarate in the presence of (Fe.sup.2+) are determined by X-ray crystallography.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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