Regulation of chemotactic networks by 'atypical' receptors

Article Abstract:

'Atypical' receptors play a role in scavenging, or altering the localization of, chemoattractant molecules through binding and/or internalizing their ligands without activating signal transduction cascades leading to cell migration. The evidence that these receptors play a role in regulating cell migration is discussed, and their therapeutic potential in human diseases is also analyzed.

Human genetics, Cell migration, Transduction, Transduction (Genetics)

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Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectors

Article Abstract:

The family of phosphoinositide 3-kinases (PI3Ks) phosphorylates the membrane lipid phosphatidylinositol, generating second messengers that direct diverse responses. The study focuses on the biochemistry and signaling pathways of P13K, with particular emphasis on chemokine (chemotactic cytokine)-directed responses.

Leukocytes, White blood cells, Phosphoinositides, Phosphatidylinositols

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Synthesis of immune modulators by smooth muscles

Article Abstract:

Smooth muscle cells play important metabolic role in various inflammatory responses. The contribution of cellular signaling pathways to pathogenesis of diverse diseases is discussed.

Genetic aspects, Muscle cells, Smooth muscle

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