Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes

Article Abstract:

The role of phosphorylation and dephosphorylation on genetic transcription was analyzed in human La antigen. The human La antigen was phosphorylated on Ser-366 and the modification process inhibited the ribonucleic acid (RNA) polymerase III (pol III) transcription activity of the human antigen. Furthermore, La can be hyperphosphorylated by casein kinase II to form phosphothreonine which also led to the inhibition of transcription. Finally, phosphorylation and dephoshorylation of La can be utilized to regulate pol III transcription in vitro.

Physiological aspects, Genetic transcription, Transcription (Genetics), RNA polymerases, Phosphorylation, Serine, Antigens

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Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii

Article Abstract:

The identification of the Ku70 subunit of DNA-dependent protein kinase (DNA-PK) as a receptor involved in Rickettsia conorii internalization is reported. Ku70 Rickettsia conorii entry sites and inhibition of Ku70 expression impairs Rickettsia conorii internalization.

Science & research, Research, Bacterial proteins, Genetic research, Rickettsia, Rickettsiae

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