Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack

Article Abstract:

Researchers have been able to produce evidence to indicate how Seven In Absentia (SINA) and Phyllopod (PHYL) interact to control the activity of the transcription repressor Tramtrack (TTK) in the Drosophila eye. It was found that levels of TTK69 and TTK88 protein are usually diminished when PHYL and SINA are present in photoreceptor cells. The ectopic expression of PHYL can reduce levels of these proteins in cone cells. It was concluded that TTK is a negative regulator of photoreceptor differentiation.

Proteolysis

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Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

Article Abstract:

Drosophila melanogaster was transfected with derivatives of the dominant human gene for ataxia to determine the mechanisms of neuronal pathology in this debilitating disease. Results reveal the formation of nuclear inclusion bodies in the neurons of transfected Drosophila followed by a late-onset degeneration. Different cell types have varying responses to the presence of the transgene and its product.

Causes of, Neurons, Ataxia

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The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye

Article Abstract:

The Drosophila eyes absent (eya) gene is required for the early stages of development of the compound eye. Mutation analysis showed that eya is required anterior to the morphogenetic furrow for eye morphogenesis. The gene codes for a nuclear protein that blocks progenitor cell death and restores eye differentiation. Three possible models for the function of the eya gene are presented.

Compound eye

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