Resistance to cefotaxime and peptidoglycan composition in Enterococcus faecalis are influenced by exogenous sodium chloride

Article Abstract:

The Enterococcus faecalis bacterium seems susceptible to cefotaxime, a cephalosporin, in vitro. The influence of NaC1 on the susceptibility of E faecalis to cefotaxime has been tested with the laboratory strain JH2 and 20 clinical strains. Increased cefotaxime resistance and the appearance of a heterogeneous resistance phenotype was the result of growth with 3% NaC1. Modifying the number of alanine-substituted precursors in the presence of NaC1 may interfere with different PBP functions and have a role in cefotaxime resistance.

Peptidoglycans, Salt, Salt (Food), Cefotaxime

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The form of folate affects the mechanisms of methotrexate resistance in Enterococcus faecium

Article Abstract:

Chemotherapy research shows that folate in its reduced form influences the resistance of antifolate methotrexate (MTX) in Enterococcus faecium bacteria. Media experiments using resistant bacterial strains E. faecium/MTX/5-HCO-H4PteGlu and E. faecium/MTX/PteGlu show that the resistance mechanism of MTX involves higher levels of dihydrofolate reductase activity in the latter organism. It also involves less production and intracellular retention of MTX containing two glutamyl residues.

Physiological aspects, Chemotherapy, Methotrexate

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Division of the genus Enterococcus into species groups using PCR-based molecular typing methods

Article Abstract:

Broad-range polymerase chain reaction analysis of the 16S ribosomal DNA of several Enterococcus species and strains of E. fecalis and species-specific hybridization studies were undertaken to determine the utility of these techniques in species- and strain-identification. A follow-up study using randomly amplified polymorphic DNA analysis showed that the genus Enterococcus can be divided into four groups with a 49% similarity level.

Usage, Bacteria, Identification and classification, Polymerase chain reaction

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