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Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans

Article Abstract:

The effect of Rho-inlfuencing transgenes on acetylcholine (ACh) release at the Caenorhabditis elegans neuromuscular junction is examined to investigate the role of Rho in regulating neurotransmitter release. The single C. elegans Rho ortholog (RHO-1) is expressed throughout the nervous system and is required for normal cell migration, cell shape regulation and neurite outgrowth.

Author: Morrison, Paul, McMullan, Rachel, Hiley, Emma, Nurrish, Stephen J.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
United States, Cell migration, Neurotransmitters

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Trio's Rho-specific GEF domain is the missing G[[alpha].sub.q] effector in C. elegans

Article Abstract:

A study providing the first insights into the relative importance of the RhoGEF and PLC[beta] G[[alpha].sub.q] effector pathways in the context of a living animal is presented. Rho-specific GEF domain is an important G[[alpha].sub.q] effector that along with PLC[beta], mediates the G[[alpha].sub.q] signaling.

Author: Jorgensen, Erik M., Lutz, Susanne, Williams, Stacey L., Charlie, Nicole K., Vettel, Christiane, Ailion, Michael, Coco, Cassandra, Tesmer, John J.G., Wieland, Thomas, Miller, Kenneth G.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
G proteins

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Rho deep in thought

Article Abstract:

Recent studies reveal that Rho GTPases have a major role to play in the neural development as well as regulating neuronal activity in the adult brain, at least in Caenorhabditis elegans.

Author: McMullan, Rachel, Nurrish, Stephen J.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Neurons

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Subjects list: Research, Caenorhabditis elegans, Rho(D) immune globulin, Genetic aspects, Mutation (Biology), Mutation
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