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The strength of selection on ultraconserved elements in the human genome

Article Abstract:

The magnitude of selection consistent with the maintenance of ultraconserved elements were estimated by analyzing the distribution of polymorphisms within these elements. The strength of selection associated with ultraconserved elements suggests that mutations in these regions might have subtle phenotypic consequences that are not easily detected in the laboratory.

Author: Wang, Jen C., Chen, Christina T.L., Cohen, Barak A.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
United States, Nucleotide sequence, Base sequence, Phenotype, Phenotypes

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Enriching the analysis of genomewide association studies with hierarchical modeling

Article Abstract:

The article describes the new approach for selecting the most-promising single-nucleotide polymorphisms (SNPs) that incorporates into the hierarchical model giving conventional results and other existing information about SNPs.

Author: Witte, John S., Chen, Gary K.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Human genome

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Subjects list: Research, Single nucleotide polymorphisms
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